Hi
everyone. The topic of today is very interesting for me and related to the
career I study. I am taking a subject called ‘’Pharmacology of Systems l’’ and
in this course I have learned about different types of drugs, one of them ‘’antiparkinsonians’’.
Parkinson’s
disease is a neurodegenerative illness characterized by an alteration of
physical movement. Why does this disease occur? What
has been studied are the neurochemical changes that occur in the brain and it
has been found that patients suffering from this disease do not have the
colouration of the ''substance nigra'' in the brain because this area has
abundant dopaminergic neurons, that is, these people suffer the death of this
type of neurons.
Therefore
in this disease the dopaminergic control of the loco motor function is lost. A
destruction of these neurons is produced and the control they exert is lost,
and as a consequence of this loss the gabaergic neuron also loses control over
the movement. This is why therapies focus on increasing dopamine or decreasing
cholinergic stimulation.
Some
symptoms of people with Parkinson’s are: problems walking, trembling hands,
hypotension, excessive salivation when talking and increased sweating.
The drug
most used in this disease is the ‘’Levodopa’’, which is transformed into
dopamine in the brain to increase its concentration in the synaptic space and
can act on dopamine receptors, it is also a safe drug since it has few adverse
effects.
It is
important to know that in Chile, the prevalence of this disease is only 0,3% of
the population.

