CNS - Antiparkinsonians

Hi everyone. The topic of today is very interesting for me and related to the career I study. I am taking a subject called ‘’Pharmacology of Systems l’’ and in this course I have learned about different types of drugs, one of them ‘’antiparkinsonians’’.

Parkinson’s disease is a neurodegenerative illness characterized by an alteration of physical movement. Why does this disease occur?   What has been studied are the neurochemical changes that occur in the brain and it has been found that patients suffering from this disease do not have the colouration of the ''substance nigra'' in the brain because this area has abundant dopaminergic neurons, that is, these people suffer the death of this type of neurons.

Therefore in this disease the dopaminergic control of the loco motor function is lost. A destruction of these neurons is produced and the control they exert is lost, and as a consequence of this loss the gabaergic neuron also loses control over the movement. This is why therapies focus on increasing dopamine or decreasing cholinergic stimulation.

Some symptoms of people with Parkinson’s are: problems walking, trembling hands, hypotension, excessive salivation when talking and increased sweating.

The drug most used in this disease is the ‘’Levodopa’’, which is transformed into dopamine in the brain to increase its concentration in the synaptic space and can act on dopamine receptors, it is also a safe drug since it has few adverse effects.

It is important to know that in Chile, the prevalence of this disease is only 0,3% of the population.

Post Graduate Studies

Hi everyone! Start writing about this topic is not easy for me. I think that I still have so many years left to finish my career or in situations that may occur during this period that would mean I would be late to finish it.

But well, looking at it from another point of view, it is good to start learning about the variety of specialisations that currently exist related to my career (chemistry and pharmacy), because that is how we get the idea from where we could focus our studies. Also, studying this type of program would obviously mean greater knowledge and new skills that would train me as a professional with greater experience.

With the information I have, I liked the PhD program in Pharmaceutical Sciences, which could be done in the future. The curriculum consists of advanced pharmaceutical science and technology and research units. To finish the doctorate, a thesis must be submitted that contributes to the scientific knowledge in this area. I would like to study it in this University but if it were given the opportunity to do it abroad through some scholarship, I would happily do it!

If you ever did this study program, it would be ideal to do it in a part-time system, since with work and study it would be very stressful.

Another good option would be a Post Graduate since they are less years old and even then a refinement and updating of a specific discipline is achieved (Therapeutic equivalence could be a great option).

My future job

Hi everyone. In this post I will write about my future job.

 I would really work on the area I am currently studying, chemistry and pharmacy, especially in assistance area or in a laboratory.

These works are carried out in hospitals and laboratories, therefore it could not work outdoors but I would not have problems with that because I’ve always liked to be in contact with people and be able to help them. This would be in the case of working in hospitals or clinics and if I work in a pharmaceutical laboratory I will also be surrounded by a work team and machines.

The salary of both jobs is approximately over a million (or that the teachers have told us in the introductory courses of the careers).

Obviously I would love to be able to travel for work but I do not think that this can happen unless it is for congresses or trainings.

My plan so far would be to graduate and work the the first year in community pharmacy, either private or public, and save money to be able to travel, since in this area (community) the salary is quite good, even when one begins to work.

After traveling and savings money, I would like to study a major in clinical pharmacy, because I believe that a pharmacist can be good in a medical team to evaluate and treat the patient’s illness.

About love, pets and friendship

Hi everyone. The post of today is special for me because I can tell you about my favourite animal, my pet called ‘’Oso’’.

My little dog came to our family trough an aunt, since she adopted it at a fair. When we were visiting to my aunt, she did not have it in good condition. With my brother had always wanted to have a pet, so we saw the perfect opportunity to give this puppy a better home.

We had never had a pet in the family so we prepared a lot to wait for him, we bought him clothes, comb to brush, food, cookies and everything necessary.

We were looking forward to it until the day arrived that we went looking for it and brought it home. He arrived so small and scared, but I knew we were going to be very happy with him.

Everything was fine; we gave a lot of love and affection to him until day, when it had been approximately two months since he got home, he became ill with pancreatitis. In the veterinary, the doctors had to operate it and my puppy was very bad for a few weeks, until he was able to recover. Today, after five years, he is a happy and healthy dog.

My dog is very cute and tender, we always play to throw and catch a ball and he shows me his love licking me haha.

With my puppy I learned about love for dogs and the care they deserve. He transmits everything to me with eyes, his tail and his licks.

My favourite book and film

Hi everyone, today I am writing about my favourite book and film. When thinking about a book I remember my language’s class of the school, because the truth is that I don’t like very much reading but this book I liked very much.

On the four high school I had to read ‘’Brave New World’’ from the author Aldous Huxley,  this book is a dystopian novel largely set in a futuristic World State of genetically modified citizens and an intelligence-based social hierarchy. 

What I liked most was the world described in the novel as it is a utopia although ironic and ambiguous, where everyone is supposedly happy but they have eliminated other things like family, art, culture, science, philosophy and the love. 

If people read it, they could understand that the scientific advance should be careful and that the fundamental things of life should not be lost.

On the other hand, my favourite film is ‘’Harry Potter and the Prisoner of Azkaban’’. The reason why I like this movie is because the plot is interesting and striking considering that appeared new characters will be important for the history development. 
At least once in the month I see this movie (and the other of the saga) because on the TNT channel they always do marathons haha. I recommend this movie and the complete saga to people who want to entertain themselves with fiction and magical things.

                                                                                                                                      

         

My best holiday :)

For me always the best holidays are with the family, this is why my best trip to this moment has been the one I made to Machu Picchu, Peru. This trip I made with my parents, my uncles and my cousins in February of 2017.

First of all, I must say that this trip was a true adventure for all due to the long road we traveled to reach our destination. The first thing we did was take a plane from Santiago to Arica, and then cross the border. This could be done through buses or taxis and the destination was the city of Tacna. We stayed a couple of days in that city where we walked and ate at a low price. Then we continued traveling by bus to the city of Arequipa, which lasted approximately six hours. Here we still had a long way to go even though we took another bus that would take us to Cusco. 

In this city we hired a tour to Machu Picchu.The next day a car passed us to retire to the hostel to take us to a ''hydroelectric''. From there we had to walk for 3 hours next to the train line to get to Machu Picchu. This walk was really beautiful and exhausting, we were surrounded by huge mountains, rivers and vegetation.When we arrived to the town we stayed and the next day in the morning we climbed to the ruins of Machu Picchu. 

Definitely get up there and know about the ruins and civilization in addition to appreciating the landscape has been one of the most beautiful experiences of my life.

                               

A country I would like to visit

Hi everyone! Today we starting with the session blogs and we must talk in the first post about a country I would like to visit.

A few years ago, a cousin travelled to Playa del Carmen, Mexico and I loved all the photos and their experiences that told me, is why I would like visit Mexico.

I know about  Mexico beaches, their typical food, for example tacos or burritos. The climate in the country is temperate and with tropical zones. I’ve also always heard about the typical music known as Mariachi group. In this place, specifically in Playa del Carmen, I would like swimming with dolphins, although I would do it only if they have the dolphins properly cared for. Also I would love to try all the typical food because I love to eat and the species that they use should be delicious.

Without a doubt I would live in this country because it would be a quieter lifestyle and would be surrounded by beautiful landscapes.

Post 10

Hi everyone! The post of today is special because is the number 10, and this is the final blog.

This semester turned out to be longer than normal due to student strike that we lived in the faculty, but finally it is coming to an end although we are all anxious waiting for results and trying to pass the subjects.

This time at university was very difficult and stressful for me because I had six subjects and one of them I am studying for the second time, but despite this I feel that I have learned a lot in all the courses.

An achievement of this academic semester would be to exempt me from the subject I am taking for the second time (Physico-chemistry), although there are still missing notes that the teacher must deliver, I think it is most likely.

Something that has not gone very well lately is that my grandmother who lives in the countryside has been very sick and was even hospitalized so I have been somewhat worried and sad. At least, now she has improved a little and is at home.

In general so far this year has been very good, since my family, friends and boyfriend have always been there to support me and give me spirits when I need it most.

Free Post

Hi everyone! Today the topic is free and I decided to tell you about a trip that I made in 2017. With my parents, my cousins, my uncle and my aunt travelled to Perú, Machu Picchu.

First, we take an aeroplane from Santiago until Arica. In Arica live my grandfather (father of my mom) with his wife. When we arrived, we went go to his house to have lunch and went to a bus terminal to cross the border with Perú. This was chaotic because there were a lot of people and the buses did not have enough capacity for all. When we finally crossed we arrived at Tacna and we were two days. Although the city doesn’t very beautiful, the shops were inexpensive and the food was delicious. Then, we travelled to Arequipa, it was an exhausting trip because the road has many curves and the journey lasts six hours. We all arrived dizzy and early in the morning so we decided to continue travelling to Cusco (twelve hours on a bus).  Finally, we travelled from Cusco until Machu Picchu in a car and walking by the train's side. The trip was wonderful and risky, the landscape was beautiful because there was a lot of vegetation, rivers and waterfalls. Then, in Machu Picchu, I was amazed at the ruins, the landscape and the energy of the place.

My favorite Subject

Hi everyone! In this post I will write about my favorite subject of my fifth semester at the university.

Of my 6 courses that I have, the one I most enjoy studying was General Pharmacology. 

This course has as requirements two subjects, '' Systems Physiology '' and '' Chemical Analysis Laboratory ''. In this course, there are theoretical classes, where the theme to study are the processes of Absorption, Distribution, Metabolism and Excretion of the drugs, Theory of the Receptors and Preclinical Studies of the drugs. In addition to the classes, we have laboratories and seminars although this semester we only had three of each. 

In the laboratories we did different activities such as evaluating the percentage of binding of the drug to transporting proteins, predicting the absorption of the drug and analyzing the metabolization. On the other hand, the seminars consisted of evaluating the results obtained in laboratories and reading scientific article related to the topic. All this was evaluated with controls.

This subject is very important for me because it is the basis for the subjects that come later. I liked it because I learned about the processes that the drug undergoes in the organism to cause an effect and the conditions that the potential molecules must have to become drugs, which was very interesting.

My favorite website (related to my carrer)

Hi everyone! In this opportunity I writing about a career related website. In the actuality, I don’t use many websites for study because I prefer books and teaching material but exist a website that in my first year at the university helped me a lot. This website is a Youtube channel called ‘’UNICOOS’’ ( this is the link: https://www.youtube.com/user/davidcpv ), in which you can find videos of chemistry, physics, mathematics and technology.

I like the videos of this channel because they are classified information by theme, for example, there is a playlist about aromatic compounds or and much video complements.

It helps me a lot to study for different subjects and especially for Physics 1 (Mechanics) because it was very difficult for me in the first year. 

I used this website always that I will have a control or test, I mean, every day of the week.

 I would recommend this website for all students who need extra help either level of school or university because there are diverse topics available.